Overexpression of nuclear AR-V7 protein in primary prostate cancer is an independent negative prognostic marker in men with high-risk disease receiving adjuvant …
Background Overexpression of the androgen receptor (AR) splice variant 7 (AR-V7) has
recently been reported to be associated with resistance to antihormonal therapy. Herein, we
address the question whether tumor cells with AR-V7 expression can be detected at the time
of radical prostatectomy, that is, before long-term hormonal manipulation and castration
resistance, and what the potential prognostic impact on the biochemical recurrence (BCR)-
free survival may be. Methods An anti-AR-V7 antibody was first validated in a training set of …
recently been reported to be associated with resistance to antihormonal therapy. Herein, we
address the question whether tumor cells with AR-V7 expression can be detected at the time
of radical prostatectomy, that is, before long-term hormonal manipulation and castration
resistance, and what the potential prognostic impact on the biochemical recurrence (BCR)-
free survival may be. Methods An anti-AR-V7 antibody was first validated in a training set of …