The Novel Activation of ABL by Fusion to an ets-related Gene, TEL
P Papadopoulos, SA Ridge, CA Boucher, C Stocking… - Cancer research, 1995 - AACR
P Papadopoulos, SA Ridge, CA Boucher, C Stocking, LM Wiedemann
Cancer research, 1995•AACRIn human leukemia, activation of the ABL proto-oncogene locus on chromosome 9 most
commonly occurs as a result of its fusion to the BCR locus on chromosome 22. The resulting
chimeric protein displays an elevated tyrosine kinase activity. We have identified a novel
activation of ABL which involves a gene located on chromosome 12, designated TEL. Like
BCR, TEL is fused in-frame with ABL and produces a fusion protein with an elevated
tyrosine kinase activity when assayed in an immune complex. The amino-terminal …
commonly occurs as a result of its fusion to the BCR locus on chromosome 22. The resulting
chimeric protein displays an elevated tyrosine kinase activity. We have identified a novel
activation of ABL which involves a gene located on chromosome 12, designated TEL. Like
BCR, TEL is fused in-frame with ABL and produces a fusion protein with an elevated
tyrosine kinase activity when assayed in an immune complex. The amino-terminal …
Abstract
In human leukemia, activation of the ABL proto-oncogene locus on chromosome 9 most commonly occurs as a result of its fusion to the BCR locus on chromosome 22. The resulting chimeric protein displays an elevated tyrosine kinase activity. We have identified a novel activation of ABL which involves a gene located on chromosome 12, designated TEL. Like BCR, TEL is fused in-frame with ABL and produces a fusion protein with an elevated tyrosine kinase activity when assayed in an immune complex. The amino-terminal sequences of TEL encode a helix-loop-helix motif which may mediate dimerization.
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