TEL is a gene frequently involved in specific chromosomal translocations in human
leukemia and sarcoma that encodes a member of the ETS family of transcriptional
regulators. TEL is unusual among other ETS proteins by its ability to self-associatein vivo, a
property that is essential to the oncogenic activation of TEL-derived fusion proteins. We
show here that TEL is a sequence-specific transcriptional repressor of ETS-binding site-
driven transcription of model and natural promoters. Deletion of the oligomerization domain …