[HTML][HTML] Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B
H Friedle, W Knöchel - Journal of Biological Chemistry, 2002 - ASBMB
The Xvent family of homeobox transcription factors is essential for the establishment of the
dorsal-ventral body axis during Xenopus embryogenesis. In contrast toXvent-2B and other
members of the Xvent-2 subfamily, Xvent-1B is not a direct response gene of bone
morphogenetic protein-4 signaling. Xvent-1B is activated by Xvent-2, but CHX experiments
revealed the requirement of additional factors. In this study, we report on the cooperative
effect of Xvent-2 and the zinc finger transcription factor GATA-2 on the promoter of the Xvent …
dorsal-ventral body axis during Xenopus embryogenesis. In contrast toXvent-2B and other
members of the Xvent-2 subfamily, Xvent-1B is not a direct response gene of bone
morphogenetic protein-4 signaling. Xvent-1B is activated by Xvent-2, but CHX experiments
revealed the requirement of additional factors. In this study, we report on the cooperative
effect of Xvent-2 and the zinc finger transcription factor GATA-2 on the promoter of the Xvent …