Transcriptional networks orchestrate complex developmental processes. Such networks are
commonly instigated by master regulators of development. Considerable progress has been
made in elucidating GATA factor-dependent genetic networks that control blood cell
development. GATA-2 is required for the genesis and/or function of hematopoietic stem
cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of
the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves …