[HTML][HTML] Truncation of murine CaV1. 2 at Asp-1904 results in heart failure after birth
K Domes, J Ding, T Lemke, A Blaich… - Journal of Biological …, 2011 - ASBMB
The carboxyl-terminal intracellular tail of the l-type Ca 2+ channel Ca V 1.2 modulates
various aspects of channel activity. For example, deletion of the carboxyl-terminal sequence
at Ser-1905 increased Ca V 1.2 currents in an expression model. To verify this finding in an
animal model, we inserted three stop codons at the corresponding Asp-1904 in the murine
Ca V 1.2 gene. Mice homozygous for the Stop mutation (Stop/Stop mice) were born at a
Mendelian ratio but died after birth. Stop/Stop hearts showed reduced beating frequencies …
various aspects of channel activity. For example, deletion of the carboxyl-terminal sequence
at Ser-1905 increased Ca V 1.2 currents in an expression model. To verify this finding in an
animal model, we inserted three stop codons at the corresponding Asp-1904 in the murine
Ca V 1.2 gene. Mice homozygous for the Stop mutation (Stop/Stop mice) were born at a
Mendelian ratio but died after birth. Stop/Stop hearts showed reduced beating frequencies …