[HTML][HTML] Cardiac-specific Overexpression of the α1 Subunit of the L-type Voltage-dependent Ca2+ Channel in Transgenic Mice: LOSS OF ISOPROTERENOL …
JN Muth, H Yamaguchi, G Mikala, IL Grupp… - Journal of Biological …, 1999 - ASBMB
The l-type voltage-dependent calcium channel (l-VDCC) regulates calcium influx in cardiac
myocytes. Activation of the β-adrenergic receptor (βAR) pathway causes phosphorylation of
thel-VDCC and that in turn increases Ca 2+ influx. Targeted expression of the l-VDCC α 1
subunit in transgenic (Tg) mouse ventricles resulted in marked blunting of the βAR pathway.
Inotropic and lusitropic responses to isoproterenol and forskolin in Tg hearts were
significantly reduced. Likewise, Ca 2+ current augmentation induced by iso-proterenol and …
myocytes. Activation of the β-adrenergic receptor (βAR) pathway causes phosphorylation of
thel-VDCC and that in turn increases Ca 2+ influx. Targeted expression of the l-VDCC α 1
subunit in transgenic (Tg) mouse ventricles resulted in marked blunting of the βAR pathway.
Inotropic and lusitropic responses to isoproterenol and forskolin in Tg hearts were
significantly reduced. Likewise, Ca 2+ current augmentation induced by iso-proterenol and …