Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels

TW Secomb, R Hsu, RD Braun, JR Ross… - Oxygen transport to …, 1998 - Springer
TW Secomb, R Hsu, RD Braun, JR Ross, JF Gross, MW Dewhirst
Oxygen transport to tissue XX, 1998Springer
Hypoxic cancer cells are resistant to irradiation and to some types of chemotherapy. When
these methods are used to treat tumors, presence of small hypoxic regions can compromise
the outcome. Therefore, it is important to understand the factors determining the partial
pressure of oxygen (pO 2) in tumors at the microscopic level. These factors include the
oxygen supply to the tumor, which depends on the flow rate and oxygen content of blood
and the arrangement of microvessels within the tissue, and the rate of oxygen consumption …
Abstract
Hypoxic cancer cells are resistant to irradiation and to some types of chemotherapy. When these methods are used to treat tumors, presence of small hypoxic regions can compromise the outcome. Therefore, it is important to understand the factors determining the partial pressure of oxygen (pO2) in tumors at the microscopic level. These factors include the oxygen supply to the tumor, which depends on the flow rate and oxygen content of blood and the arrangement of microvessels within the tissue, and the rate of oxygen consumption by the tissue (Vaupel, 1979).
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