[HTML][HTML] Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity
E Barzilay, N Ben-Califa, L Supino-Rosin… - Journal of Biological …, 2004 - ASBMB
Geldanamycin, an ansamycin antibiotic that specifically inhibits heat-shock protein-90
(HSP90) and its endoplasmic reticulum homologue, glucose-regulated protein-94 (GRP94),
accelerates the degradation of selected cellular proteins. We showed previously that
geldanamycin inhibits maturation and transport of the epidermal growth factor receptor in
addition to accelerating its degradation (Supino-Rosin, L., Yoshimura, A., Yarden, Y., Elazar,
Z., and Neumann, D.(2000) J. Biol. Chem. 275, 21850-21855). Here we demonstrate that the …
(HSP90) and its endoplasmic reticulum homologue, glucose-regulated protein-94 (GRP94),
accelerates the degradation of selected cellular proteins. We showed previously that
geldanamycin inhibits maturation and transport of the epidermal growth factor receptor in
addition to accelerating its degradation (Supino-Rosin, L., Yoshimura, A., Yarden, Y., Elazar,
Z., and Neumann, D.(2000) J. Biol. Chem. 275, 21850-21855). Here we demonstrate that the …