Learning from nature: advances in geldanamycin-and radicicol-based inhibitors of Hsp90
RRA Kitson, CJ Moody - The Journal of organic chemistry, 2013 - ACS Publications
RRA Kitson, CJ Moody
The Journal of organic chemistry, 2013•ACS PublicationsNatural products have been fundamental in the development of new therapeutic agents
predicated on the inhibition of heat shock protein 90 (Hsp90). This Perspective describes the
influential role of the benzoquinone ansamycin geldanamycin and the resorcylic acid
macrolactone radicicol not only in driving forward drug discovery programs but also in
inspiring organic chemists to develop innovative methodology for the synthesis of natural
products and analogues with improved properties.
predicated on the inhibition of heat shock protein 90 (Hsp90). This Perspective describes the
influential role of the benzoquinone ansamycin geldanamycin and the resorcylic acid
macrolactone radicicol not only in driving forward drug discovery programs but also in
inspiring organic chemists to develop innovative methodology for the synthesis of natural
products and analogues with improved properties.
Natural products have been fundamental in the development of new therapeutic agents predicated on the inhibition of heat shock protein 90 (Hsp90). This Perspective describes the influential role of the benzoquinone ansamycin geldanamycin and the resorcylic acid macrolactone radicicol not only in driving forward drug discovery programs but also in inspiring organic chemists to develop innovative methodology for the synthesis of natural products and analogues with improved properties.
ACS Publications