[HTML][HTML] IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria
Specific components of the intestinal microbiota are capable of influencing immune
responses such that a mutualistic relationship is established. In mice, colonization with
segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the
intestine, yet the effector functions of interleukin (IL)-17A in response to SFB remain
incompletely understood. Here we report that colonization of mice with SFB-containing
microbiota induced IL-17A-and CXCR2-dependent recruitment of neutrophils to the ileum …
responses such that a mutualistic relationship is established. In mice, colonization with
segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the
intestine, yet the effector functions of interleukin (IL)-17A in response to SFB remain
incompletely understood. Here we report that colonization of mice with SFB-containing
microbiota induced IL-17A-and CXCR2-dependent recruitment of neutrophils to the ileum …