Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway
D Hong, YP Bai, HC Gao, X Wang, LF Li, GG Zhang… - Atherosclerosis, 2014 - Elsevier
Objective To investigate the effect of lectin-like ox-LDL receptor-1 (LOX-1) on oxidized low-
density lipoprotein (ox-LDL)-induced apoptosis and the involvement of the endoplasmic
reticulum (ER) stress response pathway. Methods and results Human umbilical vein
endothelial cells were treated with 50, 100, or 200 μg/ml ox-LDL and cultured for 12, 24, or
48 h for concentration-and time-dependent studies. Cells were transfected with LOX-1 or
Nox-4 shRNAs, and target proteins were inhibited with the corresponding antibodies for …
density lipoprotein (ox-LDL)-induced apoptosis and the involvement of the endoplasmic
reticulum (ER) stress response pathway. Methods and results Human umbilical vein
endothelial cells were treated with 50, 100, or 200 μg/ml ox-LDL and cultured for 12, 24, or
48 h for concentration-and time-dependent studies. Cells were transfected with LOX-1 or
Nox-4 shRNAs, and target proteins were inhibited with the corresponding antibodies for …