[HTML][HTML] FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis
SK Natarajan, BA Stringham, AM Mohr… - Journal of lipid …, 2017 - ASBMB
Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid
levels. These toxic fatty acids can induce liver cell death and our recent results
demonstrated that the biliary epithelium may be susceptible to lipotoxicity. Here, we
explored the molecular mechanisms of cholangiocyte lipoapoptosis in cell culture and in an
animal model of NASH. Treatment of cholangiocytes with palmitate (PA) showed increased
caspase 3/7 activity and increased levels of cleaved poly (ADP-ribose) polymerase and …
levels. These toxic fatty acids can induce liver cell death and our recent results
demonstrated that the biliary epithelium may be susceptible to lipotoxicity. Here, we
explored the molecular mechanisms of cholangiocyte lipoapoptosis in cell culture and in an
animal model of NASH. Treatment of cholangiocytes with palmitate (PA) showed increased
caspase 3/7 activity and increased levels of cleaved poly (ADP-ribose) polymerase and …