[HTML][HTML] Streptococcus pyogenes endopeptidase O contributes to evasion from complement-mediated bacteriolysis via binding to human complement factor C1q
M Honda-Ogawa, T Sumitomo, Y Mori, DT Hamd… - Journal of Biological …, 2017 - ASBMB
Streptococcus pyogenes secretes various virulence factors for evasion from complement-
mediated bacteriolysis. However, full understanding of the molecules possessed by this
organism that interact with complement C1q, an initiator of the classical complement
pathway, remains elusive. In this study, we identified an endopeptidase of S. pyogenes,
PepO, as an interacting molecule, and investigated its effects on complement immunity and
pathogenesis. Enzyme-linked immunosorbent assay and surface plasmon resonance …
mediated bacteriolysis. However, full understanding of the molecules possessed by this
organism that interact with complement C1q, an initiator of the classical complement
pathway, remains elusive. In this study, we identified an endopeptidase of S. pyogenes,
PepO, as an interacting molecule, and investigated its effects on complement immunity and
pathogenesis. Enzyme-linked immunosorbent assay and surface plasmon resonance …