[HTML][HTML] Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events: characterization of the …
WV Graham, F Wang, DR Clayburgh, JX Cheng… - Journal of Biological …, 2006 - ASBMB
Myosin light chain kinase (MLCK) is expressed as long and short isoforms from unique
transcriptional start sites within a single gene. Tumor necrosis factor (TNF) augments
intestinal epithelial long MLCK expression, which is critical to cytoskeletal regulation. We
found that TNF increases long MLCK mRNA transcription, both in human enterocytes in vitro
and murine enterocytes in vivo. 5′-RACE identified two novel exons, 1A and 1B, which
encode alternative long MLCK transcriptional start sites. Chromatin immunoprecipitation …
transcriptional start sites within a single gene. Tumor necrosis factor (TNF) augments
intestinal epithelial long MLCK expression, which is critical to cytoskeletal regulation. We
found that TNF increases long MLCK mRNA transcription, both in human enterocytes in vitro
and murine enterocytes in vivo. 5′-RACE identified two novel exons, 1A and 1B, which
encode alternative long MLCK transcriptional start sites. Chromatin immunoprecipitation …