[HTML][HTML] Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
SC Nalle, JR Turner - Mucosal immunology, 2015 - Elsevier
Compromised intestinal barrier function is a prominent feature of inflammatory bowel
disease (IBD). However, links between intestinal barrier loss and disease extend much
further, including documented associations with celiac disease, type I diabetes, rheumatoid
arthritis, and multiple sclerosis. Intestinal barrier loss has also been proposed to have a
critical role in the pathogenesis of graft-versus-host disease (GVHD), a serious, potentially
fatal consequence of hematopoietic stem cell transplantation. Experimental evidence has …
disease (IBD). However, links between intestinal barrier loss and disease extend much
further, including documented associations with celiac disease, type I diabetes, rheumatoid
arthritis, and multiple sclerosis. Intestinal barrier loss has also been proposed to have a
critical role in the pathogenesis of graft-versus-host disease (GVHD), a serious, potentially
fatal consequence of hematopoietic stem cell transplantation. Experimental evidence has …