Novel strategies for the treatment and diagnosis of graft-versus-host-disease
JLM Ferrara - Best Practice & Research Clinical Haematology, 2007 - Elsevier
Graft-versus-host disease (GVHD) is a serious complication of hematopoietic stem cell
transplantation. The main clinical targets of GVHD are the skin, liver, gastrointestinal tract,
and possibly the lung. The standard initial therapy for GVHD includes the use of high-dose
steroids, which result in an unsatisfactory complete response (CR) rate of about 40% and
the need to develop more effective therapies. The Clinical Trial Network is conducting a four-
arm randomized phase II study evaluating prednisone in combination with one of the …
transplantation. The main clinical targets of GVHD are the skin, liver, gastrointestinal tract,
and possibly the lung. The standard initial therapy for GVHD includes the use of high-dose
steroids, which result in an unsatisfactory complete response (CR) rate of about 40% and
the need to develop more effective therapies. The Clinical Trial Network is conducting a four-
arm randomized phase II study evaluating prednisone in combination with one of the …