[HTML][HTML] Adenomatous polyposis coli (APC) differentially regulates β-catenin phosphorylation and ubiquitination in colon cancer cells

J Yang, W Zhang, PM Evans, X Chen, X He… - Journal of Biological …, 2006 - ASBMB
Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or
the β-catenin gene that stabilize β-catenin and activate β-catenin target genes, leading
ultimately to cancer. The molecular mechanisms of APC function in β-catenin degradation
are not completely known. APC binds β-catenin and is involved in the Axin complex,
suggesting that APC regulates β-catenin phosphorylation. Some evidence also suggests
that APC regulates β-catenin nuclear export. Here, we examine the effects of APC mutations …