Wild-type MIC distributions and epidemiologic cutoff values for fluconazole, posaconazole, and voriconazole when testing Cryptococcus neoformans as determined by …

MA Pfaller, M Castanheira, DJ Diekema… - … and infectious disease, 2011 - Elsevier
When clinical susceptibility breakpoints (CBPs) are absent, establishing wild-type (WT) MIC
distributions and epidemiologic cutoff values (ECVs) provides a sensitive means for
detecting emerging resistance to antimicrobials. We determined species-specific ECVs for
fluconazole (FLC), posaconazole (PSC), and voriconazole (VRC) using a large global
collection of Cryptococcus neoformans (CNEO) isolates obtained from the ARTEMIS and
SENTRY Antimicrobial Surveillance Programs. From 2006 to 2009, 285 invasive clinical …