Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage
Recent evidences suggest a significant role of Plasmacytoid dendritic cells (PDC) role in the
pathogenesis of lupus erythematosus (LE) via production of type I IFN. Taking advantage on
the availability of multiple reagents (CD123, BDCA2, and CD2ap) specifically recognizing
PDC on fixed tissues, we investigated the occurrence of PDC in a cohort of 74 LE patients.
The large majority of LE biopsies (67/74; 90.5%) showed cutaneous infiltration of PDC. PDC
were more frequently observed (96.4 vs 72.2) and numerous in cutaneous LE compared to …
pathogenesis of lupus erythematosus (LE) via production of type I IFN. Taking advantage on
the availability of multiple reagents (CD123, BDCA2, and CD2ap) specifically recognizing
PDC on fixed tissues, we investigated the occurrence of PDC in a cohort of 74 LE patients.
The large majority of LE biopsies (67/74; 90.5%) showed cutaneous infiltration of PDC. PDC
were more frequently observed (96.4 vs 72.2) and numerous in cutaneous LE compared to …