Function and regulation of cullin–RING ubiquitin ligases

MD Petroski, RJ Deshaies - Nature reviews Molecular cell biology, 2005 - nature.com
MD Petroski, RJ Deshaies
Nature reviews Molecular cell biology, 2005nature.com
Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of
distinct cullin–RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes
as key mediators of post-translational protein regulation. In this review, we focus on the
composition, regulation and function of cullin–RING ligases, and describe how these
enzymes can be characterized by a set of general principles.
Abstract
Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin–RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin–RING ligases, and describe how these enzymes can be characterized by a set of general principles.
nature.com