Proteolytic control of the oncoprotein transcription factor Myc

LR Thomas, WP Tansey - Advances in cancer research, 2011 - Elsevier
The c-Myc oncogene encodes a multifunctional transcription factor that directs the
expression of genes required for cell growth and proliferation. Consistent with its potent
growth-promoting properties, cells have evolved numerous mechanisms that limit the
expression and activity of Myc. One of the most prominent of these mechanisms is
proteolysis, which destroys Myc within minutes of its synthesis. The rapid and controlled
destruction of Myc keeps its levels low and precisely tied to processes that regulate Myc …