[HTML][HTML] Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide …
The multimodular guanine nucleotide exchange factors (GEFs) of the Dbl family mostly
share a tandem Dbl homology (DH) and pleckstrin homology (PH) domain organization. The
function of these and other domains in the DH-mediated regulation of the GDP/GTP
exchange reaction of the Rho proteins is the subject of intensive investigations. This
comparative study presents detailed kinetic data on specificity, activity, and regulation of the
catalytic DH domains of four GEFs, namely p115, p190, PDZ-RhoGEF (PRG), and leukemia …
share a tandem Dbl homology (DH) and pleckstrin homology (PH) domain organization. The
function of these and other domains in the DH-mediated regulation of the GDP/GTP
exchange reaction of the Rho proteins is the subject of intensive investigations. This
comparative study presents detailed kinetic data on specificity, activity, and regulation of the
catalytic DH domains of four GEFs, namely p115, p190, PDZ-RhoGEF (PRG), and leukemia …