Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia

GS von Banchet, MK Boettger, C König… - Molecular and Cellular …, 2013 - Elsevier
In addition to the proinflammatory cytokines tumor necrosis factor-α, interleukin-6 and
interleukin-1ß, the cytokine interleukin-17 (IL-17) is considered an important mediator of
autoimmune diseases such as rheumatoid arthritis. Because tumor necrosis factor-α and
interleukin-1ß have the potential to influence the expression of transduction molecules such
as transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons
and thus to contribute to pain we explored in the present study whether IL-17A activates …