Association of MOG-IgG serostatus with relapse after acute disseminated encephalomyelitis and proposed diagnostic criteria for MOG-IgG–associated disorders
Importance Recent studies have reported a higher relapse rate following an initial
inflammatory demyelinating disorder in pediatric patients with persistent seropositivity of
antibodies targeting myelin oligodendrocyte glycoprotein (MOG-IgG1). To date, the clinical
implications of longitudinal MOG-IgG1 seropositivity using live cell assays with IgG1
secondary antibodies in adults after acute disseminated encephalomyelitis (ADEM) are
unknown. Objective To determine whether MOG-IgG1 serostatus (transient vs persistent) …
inflammatory demyelinating disorder in pediatric patients with persistent seropositivity of
antibodies targeting myelin oligodendrocyte glycoprotein (MOG-IgG1). To date, the clinical
implications of longitudinal MOG-IgG1 seropositivity using live cell assays with IgG1
secondary antibodies in adults after acute disseminated encephalomyelitis (ADEM) are
unknown. Objective To determine whether MOG-IgG1 serostatus (transient vs persistent) …