Brain immunohistopathological study in a patient with anti‐NMDAR encephalitis
JP Camdessanché, N Streichenberger… - European journal of …, 2011 - Wiley Online Library
JP Camdessanché, N Streichenberger, G Cavillon, V Rogemond, G Jousserand, J Honnorat…
European journal of neurology, 2011•Wiley Online LibraryBackground and purpose: Anti‐N‐methyl‐d‐asparate (NMDA) receptor encephalitis is
thought to be antibody‐mediated. To perform an immunohistopathological study of the
inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a
patient with anti‐NMDA receptor encephalitis. Methods: An immunohistochemical study was
performed using CD3, CD68, CD20, CD138 and CD1a antibodies. Results: Prominent B‐
cell cuffing was present around brain vessels accompanied by some plasma cells, while …
thought to be antibody‐mediated. To perform an immunohistopathological study of the
inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a
patient with anti‐NMDA receptor encephalitis. Methods: An immunohistochemical study was
performed using CD3, CD68, CD20, CD138 and CD1a antibodies. Results: Prominent B‐
cell cuffing was present around brain vessels accompanied by some plasma cells, while …
Background and purpose: Anti‐N‐methyl‐d‐asparate (NMDA) receptor encephalitis is thought to be antibody‐mediated. To perform an immunohistopathological study of the inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a patient with anti‐NMDA receptor encephalitis.
Methods: An immunohistochemical study was performed using CD3, CD68, CD20, CD138 and CD1a antibodies.
Results: Prominent B‐cell cuffing was present around brain vessels accompanied by some plasma cells, while macrophages and T cells were scattered throughout the brain parenchyma.
Conclusion: These findings suggest that the B cells interact with the T cells and are involved in antibody secretion by the plasma cells.
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