Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression

P Riva-Posse, KS Choi, PE Holtzheimer, CC McIntyre… - Biological …, 2014 - Elsevier
Background Subcallosal cingulate white matter (SCC) deep brain stimulation (DBS) is an
evolving investigational treatment for depression. Mechanisms of action are hypothesized to
involve modulation of activity within a structurally defined network of brain regions involved
in mood regulation. Diffusion tensor imaging was used to model white matter connections
within this network to identify those critical for successful antidepressant response. Methods
Preoperative high-resolution magnetic resonance imaging data, including diffusion tensor …