Epithelial–mesenchymal transition of renal tubules: Divergent processes of repairing in acute or chronic injury?
YS Jiang, T Jiang, B Huang, PS Chen, J Ouyang - Medical hypotheses, 2013 - Elsevier
Epithelial–mesenchymal transition (EMT) of tubular epithelial cells (TECs) is commonly
considered as the major mechanism leading to renal fibrosis in chronic kidney diseases
(CKD) injury. We raise the hypothesis that EMT in adult kidney may be an event of “atavistic”
phenotypic transition, which mimics but reverses the genetic and cellular processes of
development of renal tubules. Transformed TECs may be regarded as induced
mesenchymal stem-like cells, representing a cellular self-adaptation when in acute or …
considered as the major mechanism leading to renal fibrosis in chronic kidney diseases
(CKD) injury. We raise the hypothesis that EMT in adult kidney may be an event of “atavistic”
phenotypic transition, which mimics but reverses the genetic and cellular processes of
development of renal tubules. Transformed TECs may be regarded as induced
mesenchymal stem-like cells, representing a cellular self-adaptation when in acute or …