[HTML][HTML] Identification and characterization of a sphingolipid Δ4-desaturase family
P Ternes, S Franke, U Zähringer, P Sperling… - Journal of Biological …, 2002 - ASBMB
Sphingolipids desaturated at the Δ4-position are important signaling molecules in many
eukaryotic organisms, including mammals. In a bioinformatics approach, we now identified a
new family of protein sequences from animals, plants, and fungi and characterized these
sequences biochemically by expression inSaccharomyces cerevisiae. This resulted in the
identification of the enzyme sphingolipid Δ4-desaturase (dihydroceramide desaturase) from
Homo sapiens, Mus musculus, Drosophila melanogaster, andCandida albicans, in addition …
eukaryotic organisms, including mammals. In a bioinformatics approach, we now identified a
new family of protein sequences from animals, plants, and fungi and characterized these
sequences biochemically by expression inSaccharomyces cerevisiae. This resulted in the
identification of the enzyme sphingolipid Δ4-desaturase (dihydroceramide desaturase) from
Homo sapiens, Mus musculus, Drosophila melanogaster, andCandida albicans, in addition …