[HTML][HTML] Effects of microRNA on regulatory T cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

KL Hippen, M Loschi, J Nicholls… - Frontiers in …, 2018 - frontiersin.org
KL Hippen, M Loschi, J Nicholls, KPA MacDonald, BR Blazar
Frontiers in immunology, 2018frontiersin.org
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs)
are a family of~ 22 nucleotide non-coding RNAs that are processed from longer precursors
by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally
through mRNA destabilization or translational silencing. A critical role for miRNA in Treg
function was initially discovered when both Dicer and Drosha knockout (KO) mice were
found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.
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