CTLA-4 and T cell activation
MA Oosterwegel, RJ Greenwald, DA Mandelbrot… - Current opinion in …, 1999 - Elsevier
MA Oosterwegel, RJ Greenwald, DA Mandelbrot, RB Lorsbach, AH Sharpe
Current opinion in immunology, 1999•ElsevierThe past year has seen significant advances in our understanding of the role of cytotoxic T
lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies
indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell
responses independently of CD28. Recent work has also revealed a role for CTLA-4 in
regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity
has shown that CTLA-4 regulates both the initiation and the progression of autoimmune …
lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies
indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell
responses independently of CD28. Recent work has also revealed a role for CTLA-4 in
regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity
has shown that CTLA-4 regulates both the initiation and the progression of autoimmune …
The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1 /Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.
Elsevier