Molecular targets on mast cells and basophils for novel therapies
IT Harvima, F Levi-Schaffer, P Draber… - Journal of Allergy and …, 2014 - Elsevier
Mast cells and basophils (MCs/Bs) play a crucial role in type I allergy, as well as in innate
and adaptive immune responses. These cells mediate their actions through soluble
mediators, some of which are targeted therapeutically by, for example, H1-and H2-
antihistamines or cysteinyl leukotriene receptor antagonists. Recently, considerable
progress has been made in developing new drugs that target additional MC/B mediators or
receptors, such as serine proteinases, histamine 4-receptor, 5-lipoxygenase–activating …
and adaptive immune responses. These cells mediate their actions through soluble
mediators, some of which are targeted therapeutically by, for example, H1-and H2-
antihistamines or cysteinyl leukotriene receptor antagonists. Recently, considerable
progress has been made in developing new drugs that target additional MC/B mediators or
receptors, such as serine proteinases, histamine 4-receptor, 5-lipoxygenase–activating …