Regulation of the germinal center response by microRNA-155

TH Thai, DP Calado, S Casola, KM Ansel, C Xiao… - Science, 2007 - science.org
TH Thai, DP Calado, S Casola, KM Ansel, C Xiao, Y Xue, A Murphy, D Frendewey…
Science, 2007science.org
MicroRNAs are small RNA species involved in biological control at multiple levels. Using
genetic deletion and transgenic approaches, we show that the evolutionarily conserved
microRNA-155 (miR-155) has an important role in the mammalian immune system,
specifically in regulating T helper cell differentiation and the germinal center reaction to
produce an optimal T cell–dependent antibody response. miR-155 exerts this control, at
least in part, by regulating cytokine production. These results also suggest that individual …
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
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