Selective incorporation of cargo proteins into the forming vesicle is an important aspect of
protein targeting via vesicular trafficking. Based on the current paradigm of cargo selection
in vesicular transport, proteins to be sorted to other organelles are condensed at the vesicle
budding site in the donor organelle, a process that is mediated by the interaction between
cargo and coat proteins, which constitute part of the vesicle forming machinery. The
cytoplasm to vacuole targeting (Cvt) pathway is an unconventional vesicular trafficking …