Interleukin‐17 and interleukin‐23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?
M Rentzos, A Rombos, C Nikolaou… - Acta Neurologica …, 2010 - Wiley Online Library
Acta Neurologica Scandinavica, 2010•Wiley Online Library
Rentzos M, Rombos A, Nikolaou C, Zoga M, Zouvelou V, Dimitrakopoulos A, Alexakis T,
Tsoutsou A, Samakovli A, Michalopoulou M, Evdokimidis J. Interleukin‐17 and interleukin‐
23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17
cells activation? Acta Neurol Scand: 2010: 122: 425–429.© 2010 The Authors Journal
compilation© 2010 Blackwell Munksgaard. Background–There is evidence that
immunological factors may involved in pathogenetic mechanisms of amyotrophic lateral …
Tsoutsou A, Samakovli A, Michalopoulou M, Evdokimidis J. Interleukin‐17 and interleukin‐
23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17
cells activation? Acta Neurol Scand: 2010: 122: 425–429.© 2010 The Authors Journal
compilation© 2010 Blackwell Munksgaard. Background–There is evidence that
immunological factors may involved in pathogenetic mechanisms of amyotrophic lateral …
Rentzos M, Rombos A, Nikolaou C, Zoga M, Zouvelou V, Dimitrakopoulos A, Alexakis T, Tsoutsou A, Samakovli A, Michalopoulou M, Evdokimidis J. Interleukin‐17 and interleukin‐23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?
Acta Neurol Scand: 2010: 122: 425–429.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard.
Background – There is evidence that immunological factors may involved in pathogenetic mechanisms of amyotrophic lateral sclerosis (ALS). Th17 cells are characterized by predominant production of IL‐17 and are suggested to be crucial in destructive autoimmunity. Interleukin‐23 (IL‐23) appears to play a supporting role in the continued stimulation and survival of Th17.
Patients and methods – We measured by enzyme‐like immunosorbent assay (ELISA) serum and cerebrospinal fluid (CSF) levels of IL‐17 and IL‐23 in 22 patients with ALS and 19 patients with other non‐inflammatory neurological disorders (NIND) studied as a control group. IL‐17 and IL‐23 serum and CSF levels were also correlated with duration of the disease, the disability level and the clinical subtype of the disease onset in patients with ALS.
Results – IL‐17 and IL‐23 serum levels were higher in patients with ALS as compared with patients with NIND (P = 0.015 and P = 0.002 respectively). IL‐17 and IL‐23 CSF levels were also increased in patients with ALS (P = 0.0006 and P = 0.000001 respectively). IL‐17 and IL‐23 levels were not correlated with disease duration, disability scale or clinical subtype of the disease onset in ALS patients.
Conclusions – Our findings suggest that these molecules may be involved in the pathogenetic mechanisms acting as potential markers of Th17 cells activation in ALS.
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