Aberrant expression of platelet-derived growth factor (PDGF) and PDGF receptor-alpha is associated with advanced bone marrow fibrosis in idiopathic myelofibrosis
O Bock, G Loch, G Busche, R von Wasielewski… - …, 2005 - haematologica.org
O Bock, G Loch, G Busche, R von Wasielewski, J Schlué, H Kreipe
Haematologica, 2005•haematologica.orgThe expression of members of the platelet-derived growth factor (PDGF) system in bone
marrow cells derived from Idiopathic myelofibrosis (IMF) has been investigated by real-time
RT-PCR. Increased expression of PDGFs and the corresponding PDGF receptor a could be
demonstrated to be a feature of advanced fibrosis in IMF that is not demonstrable in the
prefibrotic phase of the disease.
marrow cells derived from Idiopathic myelofibrosis (IMF) has been investigated by real-time
RT-PCR. Increased expression of PDGFs and the corresponding PDGF receptor a could be
demonstrated to be a feature of advanced fibrosis in IMF that is not demonstrable in the
prefibrotic phase of the disease.
Abstract
The expression of members of the platelet-derived growth factor (PDGF) system in bone marrow cells derived from Idiopathic myelofibrosis (IMF) has been investigated by real-time RT-PCR. Increased expression of PDGFs and the corresponding PDGF receptor a could be demonstrated to be a feature of advanced fibrosis in IMF that is not demonstrable in the prefibrotic phase of the disease.
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