[HTML][HTML] ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo

R Mani, CL Chiang, FW Frissora, R Yan, X Mo… - Experimental …, 2015 - Elsevier
Highlights•OSU-2S exhibits potent cytotoxicity in mantle-cell lymphoma•OSU-2S increases
the surface expression of CD74 in mantle-cell lymphoma•ROR1-targeted OSU-2S
immunonanoparticle is active in vitro and in vivoMantle-cell lymphoma (MCL) remains
incurable despite numerous therapeutic advances. OSU-2S, a novel
nonimmunosuppressive FTY720 (Fingolimod) derivative, exhibits potent cytotoxicity in MCL
cell lines and primary cells. OSU-2S increased the surface expression of CD74, a …