A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness
BACKGROUND: The epithelial cell–derived protein thymic stromal lymphopoietin stimulates
dendritic and mast cells to promote proallergic TH2 responses. Studies of transgenic
expression of thymic stromal lymphopoietin and its receptor knockout mice have
emphasized its critical role in the development of allergic inflammation. Association of
genetic variation in thymic stromal lymphopoietin with IgE levels has been reported for
human subjects. OBJECTIVE: The aim of this study was to evaluate the relationship between …
dendritic and mast cells to promote proallergic TH2 responses. Studies of transgenic
expression of thymic stromal lymphopoietin and its receptor knockout mice have
emphasized its critical role in the development of allergic inflammation. Association of
genetic variation in thymic stromal lymphopoietin with IgE levels has been reported for
human subjects. OBJECTIVE: The aim of this study was to evaluate the relationship between …