Background B cells expressing IgE contribute to immunity against parasites and venoms
and are the source of antigen specificity in allergic patients, yet the developmental pathways
producing these B cells in human subjects remain a subject of debate. Much of our
knowledge of IgE lineage development derives from model studies in mice rather than from
human subjects. Objective We evaluate models for isotype switching to IgE in human
subjects using immunoglobulin heavy chain (IGH) mutational lineage data. Methods We …