This article continues the comprehensive international consensus (ICON) statement on
allergen immunotherapy (AIT). The initial article also recently appeared in the Journal. The
conclusions below focus on key mechanisms of AIT-triggered tolerance, requirements in
allergen standardization, AIT cost-effectiveness, and regulatory guidance. Potential barriers
to and facilitators of the use of AIT are described in addition to future directions. International
allergy specialists representing the European Academy of Allergy and Clinical Immunology; …