Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2
N Novak, N Mete, C Bussmann, L Maintz… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Early desensitization of FcεRI-bearing mast cells and basophils has been
demonstrated in allergen-specific immunotherapy and drug desensitization. However, its
mechanisms have not been elucidated in detail. Histamine is one of the main mediators
released on FcεRI triggering of basophils and mast cells, and it exerts its functions through
histamine receptors (HRs). OBJECTIVES: We sought to investigate HR expression on
basophils of patients undergoing venom immunotherapy (VIT) and its effect on allergen, IgE …
demonstrated in allergen-specific immunotherapy and drug desensitization. However, its
mechanisms have not been elucidated in detail. Histamine is one of the main mediators
released on FcεRI triggering of basophils and mast cells, and it exerts its functions through
histamine receptors (HRs). OBJECTIVES: We sought to investigate HR expression on
basophils of patients undergoing venom immunotherapy (VIT) and its effect on allergen, IgE …