Gene-environment interaction for childhood asthma and exposure to farming in Central Europe
MJ Ege, DP Strachan, WOCM Cookson… - Journal of allergy and …, 2011 - Elsevier
BACKGROUND: Asthma is a disease in which both genetic and environmental factors play
important roles. The farming environment has consistently been associated with protection
from childhood asthma and atopy, and interactions have been reported with polymorphisms
in innate immunity genes. OBJECTIVE: To detect gene-environment interactions for asthma
and atopy in the farming environment. METHODS: We performed a genome-wide interaction
analysis for asthma and atopy by using 500,000 genotyped single nucleotide …
important roles. The farming environment has consistently been associated with protection
from childhood asthma and atopy, and interactions have been reported with polymorphisms
in innate immunity genes. OBJECTIVE: To detect gene-environment interactions for asthma
and atopy in the farming environment. METHODS: We performed a genome-wide interaction
analysis for asthma and atopy by using 500,000 genotyped single nucleotide …