[PDF][PDF] Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases

M Spite, J Claria, CN Serhan - Cell metabolism, 2014 - cell.com
M Spite, J Claria, CN Serhan
Cell metabolism, 2014cell.com
Inflammation is associated with the development of diseases characterized by altered
nutrient metabolism. Although an acute inflammatory response is host-protective and
normally self-limited, chronic low-grade inflammation associated with metabolic diseases is
sustained and detrimental. The resolution of inflammation involves the termination of
neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of
macrophage-mediated clearance, and tissue remodeling. Specialized proresolving lipid …
Inflammation is associated with the development of diseases characterized by altered nutrient metabolism. Although an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic diseases is sustained and detrimental. The resolution of inflammation involves the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling. Specialized proresolving lipid mediators (SPMs)–resolvins, protectins, and maresins–are novel autacoids that resolve inflammation, protect organs, and stimulate tissue regeneration. Here, we review evidence that the failure of resolution programs contributes to metabolic diseases and that SPMs may play pivotal roles in their resolution.
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