Functional and pathological roles of the 12-and 15-lipoxygenases
AD Dobrian, DC Lieb, BK Cole… - Progress in lipid …, 2011 - Elsevier
The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type
2 diabetes (and associated complications), cardiovascular disease, hypertension, renal
disease, and the neurological conditions Alzheimer's disease and Parkinson's disease. A
number of elegant studies over the last thirty years have contributed to unraveling the role
that lipoxygenases play in chronic inflammation. The development of animal models with …
that are involved in a number of significant disease states. The latter include type 1 and type
2 diabetes (and associated complications), cardiovascular disease, hypertension, renal
disease, and the neurological conditions Alzheimer's disease and Parkinson's disease. A
number of elegant studies over the last thirty years have contributed to unraveling the role
that lipoxygenases play in chronic inflammation. The development of animal models with …