Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial
JM Spergel, ME Rothenberg, MH Collins… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic esophagitis is a chronic allergic disease with insufficient
treatment options. Results from animal studies suggest that IL-5 induces eosinophil
trafficking in the esophagus. OBJECTIVE: We sought to evaluate the effect of reslizumab, a
neutralizing antibody against IL-5, in children and adolescents with eosinophilic esophagitis.
METHODS: Patients with symptom severity scores of moderate or worse and an esophageal
biopsy specimen with 24 or more intraepithelial eosinophils per high-power field were …
treatment options. Results from animal studies suggest that IL-5 induces eosinophil
trafficking in the esophagus. OBJECTIVE: We sought to evaluate the effect of reslizumab, a
neutralizing antibody against IL-5, in children and adolescents with eosinophilic esophagitis.
METHODS: Patients with symptom severity scores of moderate or worse and an esophageal
biopsy specimen with 24 or more intraepithelial eosinophils per high-power field were …