Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis
LM Bartnikas, MF Gurish, OT Burton, S Leisten… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Sensitization to food antigen can occur through cutaneous exposure.
OBJECTIVE: We sought to test the hypothesis that epicutaneous sensitization with food
antigen predisposes to IgE-mediated anaphylaxis on oral allergen challenge. METHODS:
BALB/c mice were epicutaneously sensitized by repeated application of ovalbumin (OVA) to
tape-stripped skin over 7 weeks or orally immunized with OVA and cholera toxin (CT) weekly
for 8 weeks and then orally challenged with OVA. Body temperature was monitored, and …
OBJECTIVE: We sought to test the hypothesis that epicutaneous sensitization with food
antigen predisposes to IgE-mediated anaphylaxis on oral allergen challenge. METHODS:
BALB/c mice were epicutaneously sensitized by repeated application of ovalbumin (OVA) to
tape-stripped skin over 7 weeks or orally immunized with OVA and cholera toxin (CT) weekly
for 8 weeks and then orally challenged with OVA. Body temperature was monitored, and …