Measurement of Oncometabolites d-2-Hydroxyglutaric Acid and l-2-Hydroxyglutaric Acid
PM Jones, R Boriack, EA Struys, D Rakheja - Acute Myeloid Leukemia …, 2017 - Springer
PM Jones, R Boriack, EA Struys, D Rakheja
Acute Myeloid Leukemia: Methods and Protocols, 2017•SpringerWe describe a liquid chromatography-tandem mass spectrometry assay for measurement of
d-2-hydroxyglutaric acid and l-2-hydroxyglutaric acid. These metabolites are increased in
specific inborn errors of metabolism and are now recognized as oncometabolites. The
measurement of d-2-hydroxyglutarate in peripheral blood may be used as a biomarker for
screening and follow-up of patients with IDH-mutated acute myeloid leukemia.
d-2-hydroxyglutaric acid and l-2-hydroxyglutaric acid. These metabolites are increased in
specific inborn errors of metabolism and are now recognized as oncometabolites. The
measurement of d-2-hydroxyglutarate in peripheral blood may be used as a biomarker for
screening and follow-up of patients with IDH-mutated acute myeloid leukemia.
Abstract
We describe a liquid chromatography-tandem mass spectrometry assay for measurement of d-2-hydroxyglutaric acid and l-2-hydroxyglutaric acid. These metabolites are increased in specific inborn errors of metabolism and are now recognized as oncometabolites. The measurement of d-2-hydroxyglutarate in peripheral blood may be used as a biomarker for screening and follow-up of patients with IDH-mutated acute myeloid leukemia.
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