Human cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: a quantitative and histological analysis
HP Chen, JK Jiang, CY Chen, TY Chou, YC Chen… - Journal of clinical …, 2012 - Elsevier
BACKGROUND: It has long been suggested that human cytomegalovirus (HCMV) might be
involved in human oncogenesis. However, whether HCMV was associated with colorectal
cancer (CRC) was still controversial. OBJECTIVE: To clarify whether HCMV specifically
infects the tumorous tissue of CRC. STUDY DESIGN: Paired tumor and adjacent non-
neoplastic CRC specimens were collected from 163 patients. HCMV DNA was detected and
quantified through PCR and quantitative real-time PCR. Virus location was determined by in …
involved in human oncogenesis. However, whether HCMV was associated with colorectal
cancer (CRC) was still controversial. OBJECTIVE: To clarify whether HCMV specifically
infects the tumorous tissue of CRC. STUDY DESIGN: Paired tumor and adjacent non-
neoplastic CRC specimens were collected from 163 patients. HCMV DNA was detected and
quantified through PCR and quantitative real-time PCR. Virus location was determined by in …