The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated …
L BARISONI, W KRIZ, P MUNDEL… - Journal of the American …, 1999 - journals.lww.com
Podocytes are highly differentiated, postmitotic cells, whose function is largely based on
their complex cytoarchitecture. The differentiation of podocytes coincides with progressive
expression of maturity markers, including WT-1, CALLA, C3b receptor, GLEPP-1,
podocalyxin, and synaptopodin. In collapsing forms of focal segmental glomerulosclerosis
(FSGS), including idiopathic FSGS and HIV-associated nephropathy, podocytes undergo
characteristic, irreversible ultrastructural changes. This study analyzes the expression …
their complex cytoarchitecture. The differentiation of podocytes coincides with progressive
expression of maturity markers, including WT-1, CALLA, C3b receptor, GLEPP-1,
podocalyxin, and synaptopodin. In collapsing forms of focal segmental glomerulosclerosis
(FSGS), including idiopathic FSGS and HIV-associated nephropathy, podocytes undergo
characteristic, irreversible ultrastructural changes. This study analyzes the expression …