[HTML][HTML] Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via up-regulation of ErbB4 and Notch-1
HW Lee, SQ Khan, S Khaliqdina, MM Altintas… - Journal of Biological …, 2017 - ASBMB
Podocyte injury is an early event in diabetic kidney disease and is a hallmark of
glomerulopathy. MicroRNA-146a (miR-146a) is highly expressed in many cell types under
homeostatic conditions, and plays an important anti-inflammatory role in myeloid cells.
However, its role in podocytes is unclear. Here, we show that miR-146a expression levels
decrease in the glomeruli of patients with type 2 diabetes (T2D), which correlates with
increased albuminuria and glomerular damage. miR-146a levels are also significantly …
glomerulopathy. MicroRNA-146a (miR-146a) is highly expressed in many cell types under
homeostatic conditions, and plays an important anti-inflammatory role in myeloid cells.
However, its role in podocytes is unclear. Here, we show that miR-146a expression levels
decrease in the glomeruli of patients with type 2 diabetes (T2D), which correlates with
increased albuminuria and glomerular damage. miR-146a levels are also significantly …